Pharmaceutical forms Activity Indications Interactions Precautions Dosage Adverse Reactions		INTERACTIONS Food reduces azithromycin absorption rate therefore it should be taken one hour before or two hours after a meal. Antacids affect azithromycin absorption rate. An interval of at least two hours between administration of azithromycin and an antacid is recommended. In patients receiving ergot alkaloids, ergotism can be precipitated by co-administration of some macrolide antibiotics, but there are no data concerning the possibility of an interaction between ergot derivates and azithromycin. Macrolide antibiotics are known to interact with digoxin, cyclosporin, astemizole, triazolam, midazolam or alfentanyl. Although there are no data about interactions of azithromycin and above mentioned drugs, careful monitoring of concomitant use of these drugs is recommended. The effect of azithromycin on the blood levels of theophylline, terphenadine, warfarine, carbamazepine, methylprednisolone and cimetedine has not been observed. Unlike majority of macrolides, azithromycin does not bind to cytochrom P-450 and so far no interactions with azithromycin and stated drugs have been observed. Interactions of Sumamed, clarithromycin and erythromycin Copyright 2001-2007 Pliva Hrvatska d.o.o. All rights reserved. Last change made: 28.03.2007.