Why to use Sumamed in the treatment of RTI? · Because it has low potential for interaction with other drugs Due to the fact that Sumamed is not metabolysed through P 450 system, it does not effect metabolysm of other drugs. Other macrolides are frequently involved in drug to drug interactions! Copyright 2001-2004 Pliva Hrvatska d.o.o. All rights reserved. Last change made: 28.05.2004.